Monoclonal outbreak caused by ceftazidime-avibactam resistant blaOXA-48-positive, carbapenem-resistant Klebsiella pneumoniae in an intensive care unit

This study evaluated an intensive care unit outbreak caused by a clone resistant to CAZ-AVI, which has been reported to have susceptibility rates of up to 100% in OXA-48-producing CRKP isolates and is suggested as first choice therapy. To prevent the spread of CAZ-AVI-resistant CRKP isolates, it is essential to conduct active surveillance studies in hospitals. Especially ICUs - where these strains are common - should be routinely screened. Infection control practices in general must also be tightened.