Inhibition of TREM1 attenuates myocardial ischemia-reperfusion injury-induced cardiomyocyte pyroptosis by suppressing the activation of the NF-κB signaling pathway
Our findings indicate that inhibition of TREM-1 alleviates cardiomyocyte pyroptosis during MIRI by suppressing activation of the NF-κB signaling pathway. Therefore, TREM-1 may represent a promising therapeutic target for the treatment of myocardial ischemia-reperfusion injury.
Authors
- Liang Cai
- Xuan Dang (ORCID: https://orcid.org/0000-0002-4263-4883)
- Xiaohui Xu
- Yan Kou
- Chunyan Rong
- Jianbin Han
Institutions
- Harbin Engineering University (CN)
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Heilongjiang University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1371/journal.pone.0340382
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00