Bridging Neuroimaging and Pathology in Dementia: A Multi‐Cohort Investigation of MRI‐Derived Brain Volumes

These findings highlight the potential of MRI-derived volumetrics as non-invasive biomarkers of underlying Alzheimer's pathology. Our findings demonstrate notable atrophy in medial temporal, lateral temporoparietal, and midline parietal regions, supporting recognized AD patterns of neurodegeneration, consistent with pivotal studies by Habes et al.,(2016), Dickerson et al.,(2009). Associations between amyloid, tau burdens and atrophy in temporal, parietal, and limbic regions underscore their diagnostic value in neurodegeneration.

Authors

Institutions

Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_105854
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Bridging Neuroimaging and Pathology in Dementia: A Multi‐Cohort Investigation of MRI‐Derived Brain Volumes

Rajeswar Kumar, Nicolas Honnorat, Karl Li, M. L. Cuccaro et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Bridging Neuroimaging and Pathology in Dementia: A Multi‐Cohort Investigation of MRI‐Derived Brain Volumes

Rajeswar Kumar, Nicolas Honnorat, Karl Li, M. L. Cuccaro, DEREK ARCHER, Tanweer Rashid, Sokratis Charisis, C. Davatzikos, Mariam Mojtabai, Sachintha Ransara Brandigampala, Susan M. Resnick, Ngoc‐Huynh Ho, Angela L. Jefferson, Walter W. Kukull, Mohamad Habes, David M Martinez, Andrew J. Saykin, David H Wang, Sudha Seshadri, Di Wang, Arthur W. Toga, Shannon L Risacher, Duygu Tosun
article en

Abstract

These findings highlight the potential of MRI-derived volumetrics as non-invasive biomarkers of underlying Alzheimer's pathology. Our findings demonstrate notable atrophy in medial temporal, lateral temporoparietal, and midline parietal regions, supporting recognized AD patterns of neurodegeneration, consistent with pivotal studies by Habes et al.,(2016), Dickerson et al.,(2009). Associations between amyloid, tau burdens and atrophy in temporal, parietal, and limbic regions underscore their diagnostic value in neurodegeneration.

Alzheimer s & DementiaVol. 21(S2)
University of Southern California (US), Rush University Medical Center (US), University of Miami (US), The University of Texas at San Antonio Health Science Center (US), University of California, San Francisco (US), Vanderbilt University (US), University of Washington (US), Institute for Neurodegenerative Disorders (US), Dr. John T. Macdonald Foundation (US), Institute on Aging (US), National Institute on Aging (US), Indiana University School of Medicine, Indiana University – Purdue University Indianapolis (US), University of Pennsylvania (US), Vanderbilt University Medical Center (US), The University of Texas Health Science Center at Houston (US)
Openalex Percentile: Top 28%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.