Apolipoprotein E and ethnicity interaction effects on amyloid‐PET status among East Asian and Not Hispanic and Latino White people

Through recent advances in AD-related genetic cohorts, this study provided the largest-to-date overview of the association of APOE with amyloid-PET risk in East Asians. APOE ε4 alleles were associated with less amyloid deposition risk and APOE ε2 alleles were associated with higher risk than White people. These novel insights are critical to guide AD clinical trial design and research.