Radiation-Enhanced CD24 Membrane Trafficking via GPI Anchoring Mediates Antitumor Immune Evasion
Radiation enhances CD24 membrane trafficking by regulating ANAPC5/GPAA1-mediated GPI anchoring to drive cancer immune evasion, which can be circumvented by targeting CD24 to potentiate the local and abscopal antitumor effects of radiotherapy.
Authors
- Zishan Feng
- Xueping Yang (ORCID: https://orcid.org/0000-0002-9184-8116)
- K. Yang
- X. Sherry Liu
- Jingshu Meng (ORCID: https://orcid.org/0000-0002-9684-6072)
- Chao Wan (ORCID: https://orcid.org/0000-0001-8643-6662)
- Zhiyuan Zhou
- Weidong Zhong
- Yijun Wang (ORCID: https://orcid.org/0000-0001-6214-2395)
- Jiacheng Wang
- Wenwen Wei
- Yajie Sun
- Tingting Pu
- Yuhan Sheng
- Minqi Zhou
- Pengfei Li
- Wenqian Yuan
- Lingyi Kong
- Qinyan Chen
- Fang Huang
- Yue Deng
Institutions
- Precision for Medicine (United States) (US)
- Suzhou Research Institute (CN)
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1158/0008-5472.can-25-2616
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- National Key Research and Development Program of China