Engineering single-vector logic-gated CAR T cells with transgene sizes beyond current limitations
These data establish a framework for engineering logic-gated single-vector immunotherapies and provide an optimized workflow for generating CAR T cells with transgenes that exceed current size limitations.
Authors
- Divanshu Shukla
- Philipp C. Rommel (ORCID: https://orcid.org/0000-0002-9790-4086)
- Nils W. Engel (ORCID: https://orcid.org/0000-0002-3514-5686)
- Donna Gonzales (ORCID: https://orcid.org/0000-0002-5345-946X)
- Bruce Levine
- C H June
- Isabella Hodson
- Regina M Young
- James L Riley
- Julia K Malachowski
- Johannes C M van der Loo
Institutions
- Children's Hospital of Philadelphia (US)
- Parker Institute for Cancer Immunotherapy (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1136/jitc-2025-012318
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 24.20
Funders
- Gilead Sciences
- University of Pennsylvania
- Perelman School of Medicine, University of Pennsylvania
- Kite Pharma
- National Cancer Institute