Neuropsychiatric Symptoms, Gray Matter Microstructural Integrity and Alzheimer's Disease Pathology in Older Adults with Amnestic Mild Cognitive Impairment and Dementia of Alzheimer's Type

Our findings show that more severe NPS are associated with altered diffusivity in cortical regions canonically associated with the salience network, which may reflect reduced dendritic arborization complexity in these regions. Our results suggest that NPS severity may be more tightly tied to microstructural GM changes than AD pathology as measured via PET. These results support prior functional MRI studies identifying the salience network as the primary network of interest for NPS in those with AD.