Cognitive decline investigation using the Centiloid Scale in Florbetaben amyloid PET
The CL scale provides a precise and reliable method for quantifying βA deposition. It is an objective measure that supports visual assessment and minimizes false-negative or false-positive binary classifications. Reporting βA PET results with the CL scale enables normalization across different radiotracers, thereby increasing its usefulness in evaluating disease progression and treatment response. Further investigation is underway to compare the cohort's CL values with visual readings and their correlation with neuropsychological and other laboratory testing.
Authors
- Maria Rosa Alves da Silva (ORCID: https://orcid.org/0000-0001-9570-3996)
- Ana Maria Marques da Silva (ORCID: https://orcid.org/0000-0002-5924-6852)
- Cristina Sebastião Matushita (ORCID: https://orcid.org/0000-0002-7602-0433)
- Lorenza Pabst Botton
- Cristiano Schaffer Aguzzoli (ORCID: https://orcid.org/0000-0002-7378-3830)
- LUCAS PORCELLO SCHILLING
- Fernando Jacob Lazzaretti
- Andressa de Oliveira Felício
- BARBARA SUMAN BAHLIS
- Álvaro Righi de Leonço
- Fabricio Nery Garrafiel
Institutions
- Universidade Feevale (BR)
- Universidade de São Paulo (BR)
- Instituto do Cérebro (BR)
- Hospital São Lucas da PUCRS (BR)
- Global Brain Health Institute (US)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_106174
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00