Revealing the regulatory mechanism of Astragaloside IV in treating chronic heart failure through network pharmacology and animal experiments

This study demonstrates that AS-IV delays the progression of CHF, which may be achieved by inhibiting myocardial apoptosis via activating the PI3K-AKT signaling pathway. These findings have laid the foundation for research and application of AS-IV in CHF treatment.

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Publication Details

Journal
Revista Portuguesa de Cardiologia
Published
2026-01-09
DOI
https://doi.org/10.1016/j.repc.2025.10.005
Primary Topic
Traditional Chinese Medicine Analysis
Type
article
Field-Weighted Citation Impact
0.00
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article

Revealing the regulatory mechanism of Astragaloside IV in treating chronic heart failure through network pharmacology and animal experiments

Chaoqun Xing, Xuemei Zhang, Haichen Guan, Xuanan Xiang et al.
Revista Portuguesa de Cardiologia
Traditional Chinese Medicine Analysis
article

Revealing the regulatory mechanism of Astragaloside IV in treating chronic heart failure through network pharmacology and animal experiments

Chaoqun Xing, Xuemei Zhang, Haichen Guan, Xuanan Xiang, Zhiyong Yao
article en

Abstract

This study demonstrates that AS-IV delays the progression of CHF, which may be achieved by inhibiting myocardial apoptosis via activating the PI3K-AKT signaling pathway. These findings have laid the foundation for research and application of AS-IV in CHF treatment.

Revista Portuguesa de CardiologiaVol. 45(2)
Huaihua University (CN)
Good health and well-being
Openalex Percentile: Top 91%
Traditional Chinese Medicine Analysis
DOIOpen Access PDFOpenAlex
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Revealing the regulatory mechanism of Astragaloside IV in treating chronic heart failure through network pharmacology and animal experiments — Chaoqun Xing, Xuemei Zhang, et al. · Revista Portuguesa de Cardiologia (2026) | TGRS Research Map | TGRS