Differential Immunologic Effects of Short-Course and Long-Course Radiotherapy in Locally Advanced Rectal Cancer
SCRT is less lymphodepleting and induces more frequent increases in intratumoral T-cell infiltration compared with LCRT. These results are relevant to the field of radiation-immune-oncology combination studies in LARC. Furthermore, these findings may underpin early trial results, in which higher rates of response to RT-immune checkpoint inhibitor combinations have been reported with SCRT-based regimens.
Authors
- J. Graham
- Alec McDonald
- Phimmada Hatthakarnkul (ORCID: https://orcid.org/0000-0002-5274-5480)
- Séan M. O’Cathail (ORCID: https://orcid.org/0000-0001-5574-9199)
- Leia Jones
- Ross K. McMahon (ORCID: https://orcid.org/0000-0003-0827-5351)
- Jean A. Quinn (ORCID: https://orcid.org/0000-0002-8267-0993)
- Paul G. Horgan (ORCID: https://orcid.org/0000-0001-5557-7905)
- Colin William Steele (ORCID: https://orcid.org/0000-0001-8518-1223)
- Lydia Melissourgou-Syka (ORCID: https://orcid.org/0000-0002-0926-2328)
- P. Dunne
- Norman Galbraith (ORCID: https://orcid.org/0000-0002-6354-6946)
- Raheleh Amirkhah (ORCID: https://orcid.org/0000-0003-3494-271X)
- A McCulloch (ORCID: https://orcid.org/0000-0003-4151-1563)
- Joanne Edwards
- Harikrishnan S Nair (ORCID: https://orcid.org/0000-0001-8972-5718)
- Campbell SD Roxburgh
- Annabelle Smith
- Liang Tang (ORCID: https://orcid.org/0000-0003-0446-143X)
- Walaiphorn Woraharn
- Aula Ammar
- Simon Milling
- Noori Maka
- Chia Yew Kong
- Lily V.S. Hillson
- Natalie Fisher
- Kathryn A.F. Pennel
Institutions
- Queen's University Belfast (GB)
- Beatson West of Scotland Cancer Centre (GB)
- Glasgow Royal Infirmary (GB)
- Cancer Research UK (GB)
- Queen Elizabeth University Hospital (GB)
- Varian Medical Systems (United States) (US)
- University of Glasgow (GB)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2733
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00