Association between temporal lobe cortical NODDI measures and plasma biomarkers
NODDI-derived measures (NDI and ISOVF) within the temporal lobe cortical regions demonstrate significant associations with plasma biomarkers of axonal and astrocytic dysfunction that are elevated during cognitive decline. This association provides preliminary validation of the utility of NODDI in assessing cortical microstructural changes associated with cognitive decline.
Authors
- Stephen D. Weigand (ORCID: https://orcid.org/0000-0002-4541-9011)
- Alicia Algeciras‐Schimnich (ORCID: https://orcid.org/0000-0002-4455-6217)
- Jay J. Pillai (ORCID: https://orcid.org/0000-0002-8306-7192)
- Jonathan Graff Radford
- Petrice M Cogswell
- David S. Knopman
- Ronald Petersen
- Robert I. Reid
- Clifford R. Jack
- Prashanthi Vemuri
Institutions
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_105668
- Citations
- 1
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36