Association between Mid-Trimester Serum Uric Acid Levels and the Risk of Developing GDM: A Prospective Study

Abstract Background: Gestational diabetes mellitus (GDM) is glucose intolerance that is primarily detected during pregnancy. The present study was conducted to assess the role of serum uric acid as a predictor of gestational diabetes mellitus. Materials & Methods: 90 antenatal women in first trimester were enrolled. Venous blood sample was taken from all patients and serum uric acid was measured by colorimetric assay with detection limit of 0.2- 20 mg/dl and patients were followed up at 24-28 weeks to do oral glucose tolerance test. Results: The outcome of the study was found be that, among study participants during 13-20 weeks of gestation, 77.7% had normal uric acid level, 14.44% had uric acid level more than normal and after a follow up till 24- 28 weeks Oral Glucose Tolerance Test (Oral GTT) and the results identified that, among our study participants who were diagnosed with GDM (20 participants) 13 out of 20(45%) had raised uric acid levels. Conclusion: This study showed a positive association between uric acid levels and the risk of GDM. Also, our results indicate that measuring uric acid levels before 20 weeks of gestation can potentially predict GDM.