The interplay between orexin, neurodegeneration, cognition and sleep microarchitecture in mild to moderate Alzheimer's Disease

Orexin levels are associated with neurodegeneration biomarkers and cognitive deterioration in AD and moderate relationships between sleep microarchitecture and cognitive changes over time. Orexin may thus constitute a potential target for sleep-related interventions for cognition in neurodegenerative disorders.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_107602
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
0.00
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article

The interplay between orexin, neurodegeneration, cognition and sleep microarchitecture in mild to moderate Alzheimer's Disease

Barbé Ferran, Shahla Bakian Dogaheh, Anna Carnes, Farida Dakterzada et al.
Alzheimer s & Dementia
Sleep and Wakefulness Research
article

The interplay between orexin, neurodegeneration, cognition and sleep microarchitecture in mild to moderate Alzheimer's Disease

Barbé Ferran, Shahla Bakian Dogaheh, Anna Carnes, Farida Dakterzada, Arsenio Paez, Sam O Gillman, Thien Thanh Dang‐Vu, Gerard Piñol‐Ripoll
article en

Abstract

Orexin levels are associated with neurodegeneration biomarkers and cognitive deterioration in AD and moderate relationships between sleep microarchitecture and cognitive changes over time. Orexin may thus constitute a potential target for sleep-related interventions for cognition in neurodegenerative disorders.

Alzheimer s & DementiaVol. 21(S2)
University of Oxford (GB), Hospital Universitari de Santa Maria (ES), Institut Universitaire de Gériatrie de Montréal (CA), Instituto de Investigación Biomédica de Lleida (ES), Concordia University (CA)
Openalex Percentile: Top 29%
Sleep and Wakefulness Research
DOIOpen Access PDFOpenAlex
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The interplay between orexin, neurodegeneration, cognition and sleep microarchitecture in mild to moderate Alzheimer's Disease — Barbé Ferran, Shahla Bakian Dogaheh, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS