Long‐Term Effects of Severe COVID‐19 on the Hippocampus: A 7T MRI Comparison with Alzheimer's Disease
ERC, a key gateway for neocortical input to the hippocampus, is particularly susceptible in the early stages of AD, contributing to deficits in episodic memory and spatial navigation. In ICU-Cv patients, we found selective atrophy of the ERC. This finding suggests that severe COVID-19 may lead to targeted neurodegeneration through mechanisms distinct from AD but potentially overlapping in terms of hypoperfusion, inflammation, and metabolic stress.
Authors
- Olivier Mougin (ORCID: https://orcid.org/0000-0001-9675-3530)
- Farhaan Vahidy (ORCID: https://orcid.org/0000-0002-3464-2111)
- Amin Hosseini (ORCID: https://orcid.org/0000-0002-5976-0878)
- Richard Bowtell (ORCID: https://orcid.org/0000-0001-8656-412X)
- Elizabeta B. Mukaetova‐Ladinska (ORCID: https://orcid.org/0000-0003-4985-1095)
- Tamer S. Ibrahim
- Beili Shao
- Mohammad Zia U.H Katshu
- Tales Santini
- Heidi I.L. Jacobs
- Penny Gowland
- Timothy D. Girard
- Monica Goss
- Mary Ganguli
- Oluwatobi F Adeyemi
- Sudha Seshadri
- Beth E. Snitz
Institutions
- Houston Methodist (US)
- Memorial Hermann Institute for Rehabilitation and Research Foundation (US)
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- University of Leicester (GB)
- The University of Texas at San Antonio Health Science Center (US)
- University of Pittsburgh (US)
- Massachusetts General Hospital (US)
- Institute for Neurodegenerative Disorders (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107515
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00