Evaluating the relationship of perivascular spaces with vascular risk factors, amyloid positivity, and cognitive impairment

PVS burden was significantly greater in amyloid-positive individuals compared to amyloid-negative individuals, likely due to the impaired CSF flow in the PVSs associated with glymphatic clearance. Our moderate sample size could explain the absence of associations with vascular risk factors.

Authors

Swati Rane Levendovszky (ORCID: https://orcid.org/0000-0001-8863-3168)
Mladen Zečević (ORCID: https://orcid.org/0000-0002-0437-2181)
Daniel Schwartz
Rebecca J Lepping
Lisa C Silbert
Sandra A Billinger

Institutions

Oregon Health & Science University (US)
University of Washington (US)
University of Kansas Medical Center (US)

Publication Details

Journal: Alzheimer s & Dementia
Published: 2025-12-01
DOI: https://doi.org/10.1002/alz70856_104241
Primary Topic: Cerebrospinal fluid and hydrocephalus
Type: article
Field-Weighted Citation Impact: 0.00

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article

Evaluating the relationship of perivascular spaces with vascular risk factors, amyloid positivity, and cognitive impairment

Swati Rane Levendovszky, Mladen Zečević, Daniel Schwartz, Rebecca J Lepping et al.

Dec 1, 2025

Alzheimer s & Dementia

Cerebrospinal fluid and hydrocephalus

article

Evaluating the relationship of perivascular spaces with vascular risk factors, amyloid positivity, and cognitive impairment

Swati Rane Levendovszky, Mladen Zečević, Daniel Schwartz, Rebecca J Lepping, Lisa C Silbert, Sandra A Billinger

December 1, 2025article en

Abstract

PVS burden was significantly greater in amyloid-positive individuals compared to amyloid-negative individuals, likely due to the impaired CSF flow in the PVSs associated with glymphatic clearance. Our moderate sample size could explain the absence of associations with vascular risk factors.

Alzheimer s & DementiaVol. 21(S2)

Oregon Health & Science University (US), University of Washington (US), University of Kansas Medical Center (US)

Openalex Percentile: Top 35%

Cerebrospinal fluid and hydrocephalus

DOI Open Access PDF OpenAlex

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Evaluating the relationship of perivascular spaces with vascular risk factors, amyloid positivity, and cognitive impairment — Swati Rane Levendovszky, Mladen Zečević, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS