The Critical Role of Ancillary Testing in Fine-Needle Aspiration of Lymph Nodes, Thymus, and Spleen

Ancillary studies significantly increase the diagnostic precision of FNAC, enabling lineage assignment, clonality determination, detection of defining genetic alterations, and identification of therapeutic biomarkers. These techniques are particularly valuable in paucicellular aspirates, mediastinal lesions, splenic lymphomas, and cases with overlapping morphological patterns.