Early Detection of Neuroinflammation and White Matter Damage Following Dorsal Spinal Nerve Root Sectioning in a Nonhuman Primate Model
Multiparametric MRI enables region-specific detection of spinal cord pathology, including axonal degeneration, demyelination, and possible neuroinflammation, as early as 1 week after dorsal nerve root injury. These results demonstrate its promise for noninvasive monitoring of post-injury pathology and for evaluating therapeutic efficacy.
Authors
- John C. Gore (ORCID: https://orcid.org/0000-0002-9480-0900)
- L. Chen
- Feng Wang (ORCID: https://orcid.org/0000-0002-8965-7708)
Institutions
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1002/mrm.70213
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vanderbilt University
- National Institutes of Health