Pterostilbene: An influential neuronutraceutical to effectively counteract different neuropathologies

Natural bioactive-based pharmacological treatments are now viewed as a promising long-term complement or alternative to conventional therapy. With its billions of neurons, the brain is a dynamic, intricate network that interacts to govern every bodily function. Neurodegenerative diseases can develop from the disruption of neuronal function, which is the fundamental unit of the nervous system. Growing data indicate a rise in brain-affecting conditions, which are nevertheless defined by limited treatment alternatives. The need to discover novel, non-invasive methods to stop the degeneration of neurons is crucial. Natural bioactives exhibit a diverse spectrum of chemical structures that can exert a range of pharmacological and toxicological effects, ultimately leading to neuroprotection or neurotoxicity. These pharmacodynamic qualities can have a beneficial or detrimental influence on global human and animal healthcare. Pterostilbene is a substance used in Greek, Chinese, and Ayurvedic medicine, well-known for its numerous therapeutic uses. The reported beneficial effects of resveratrol and pterostilbene have stimulated renewed scientific interest in recent years. Dimethyl ether analog of resveratrol, called Pterostilbene, is a naturally occurring bioactive that is metabolically stable and has demonstrated significant pharmacological actions. Resveratrol and pterostilbene share significant pharmacological similarities, and both are widely regarded as safe for human consumption. Most research focuses on resveratrol, with very few studies investigating pterostilbene. Thus, the current study has reviewed and included the neuro-nutraceutical value of Pterostilbene, which helps for preventive and therapeutic purposes for various neurological pathologies. Pterostilbene has been shown to be beneficial in treating various diseases affecting the central nervous system, according to research; however, there is a lack of clinical data regarding its effectiveness.