Long Duration of Type 2 Diabetes Drives Erythrocyte-Induced Vascular Endothelial Dysfunction: A Link to miRNA-210-3p
Red blood cells (RBCs) from older (representing longer duration of diabetes) but not young diabetic mice induce endothelial dysfunction. Protective miRNA-210-3p levels in RBCs are reduced in older diabetic mice compared with young ones. RBCs from individuals with long-lasting (>7 years) but not newly diagnosed type 2 diabetes (<1 year) induce endothelial dysfunction. RBCs from individuals with newly diagnosed type 2 diabetes induce endothelial dysfunction at a >7-year follow up, which is rescued by miRNA-210-3p mimic.
Authors
- Michael Alvarsson
- Eftychia Kontidou (ORCID: https://orcid.org/0000-0002-4739-6706)
- Ali Basim Mahdi (ORCID: https://orcid.org/0000-0002-2470-1317)
- Tong Jiao (ORCID: https://orcid.org/0000-0003-0925-2442)
- Aida Collado (ORCID: https://orcid.org/0000-0002-3183-2104)
- Rawan Humoud (ORCID: https://orcid.org/0009-0001-6139-3915)
- John Tengbom (ORCID: https://orcid.org/0000-0003-3608-160X)
- Zhichao Zhou (ORCID: https://orcid.org/0000-0002-5107-6529)
- Kesavan Manickam
- Jiangning Yang
- John Pernow
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Diabetes
- Published
- 2026-01-09
- DOI
- https://doi.org/10.2337/db25-0463
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00