Targeted isolation of bacteria with potential to competitively exclude Staphylococcus aureus in the upper respiratory tract of pigs
Our study, using an anticorrelation based targeted approach, identified three L. lactis strains with weak negative correlation with S. aureus, suitable for in vivo safety and efficacy testing in pigs. These L. lactis strains may have the ability to be used safely to reduce LA-MRSA carriage in the nasal passages of pigs but further in vivo testing is necessary to confirm this potential.
Authors
- Peadar G. Lawlor (ORCID: https://orcid.org/0000-0003-1571-2919)
- Julia Eckenberger (ORCID: https://orcid.org/0000-0003-4781-0660)
- Aldert Zomer (ORCID: https://orcid.org/0000-0002-0758-5190)
- Chloe E. Huseyin (ORCID: https://orcid.org/0000-0002-7517-3980)
- Christian Elend
- Birgitta Duim (ORCID: https://orcid.org/0000-0003-3568-4978)
- Abel A. Vlasblom (ORCID: https://orcid.org/0000-0002-9186-9515)
- Jaap Wagenaar
- Shriram Patel
- Daniel Crespo-Piazuelo
- Marcus J. Claesson
Institutions
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- Utrecht University (NL)
- University College Cork (IE)
- Cork County Council (IE)
- Laboratoire National de Référence (MA)
- APC Microbiome Institute (IE)
- TWT GmbH Science & Innovation (Germany) (DE)
- Wageningen University & Research (NL)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1186/s12866-025-04613-0
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Joint Programming Initiative on Antimicrobial Resistance
- Science Foundation Ireland
- ZonMw