Shared TCR Vβ21.3+ T cell immunological signature between MIS-A and MIS-C
Multisystem inflammatory syndrome (MIS) is a severe and potentially life-threatening complication of SARS-CoV-2 infection that affects both children (MIS-C) and adults (MIS-A). While the inflammatory response in MIS-C has been studied in detail, the immune dysregulation underlying MIS-A remains poorly understood, mainly due to the rarity of its condition. Using flow cytometry, we analyzed the T cell response in two, Danish and French, MIS-A cohorts, encompassing a total of 16 cases. We observed an expansion of Vβ21.3+ T cells in at least one of the major T cell subsets (CD3+, CD4+, or CD8+) in 9 out of 16 MIS-A patients. Vβ21.3+ T cells showed increased expression of activation and exhaustion markers along with a higher abundance of effector memory T cells compared to their Vβ21.3-negative counterparts in patients with or without Vβ21.3 expansion. These findings demonstrate that MIS-A shares the same Vβ21.3+ T cell signature previously reported in MIS-C, suggesting a shared pathological immune-related mechanism between the two conditions.
Authors
- Andreas Ronit (ORCID: https://orcid.org/0000-0002-8960-7524)
- Liliane Khoryati (ORCID: https://orcid.org/0000-0002-5817-8640)
- Sarah Benezech (ORCID: https://orcid.org/0000-0002-9587-3896)
- A. Belot
- Christophe Parizot (ORCID: https://orcid.org/0000-0001-5723-4471)
- Casper Roed (ORCID: https://orcid.org/0000-0001-8987-5230)
- Sofie E. Jørgensen (ORCID: https://orcid.org/0000-0002-2700-0882)
- Samira Khaldi-Plassart
- Raphaëlle Lautraite (ORCID: https://orcid.org/0000-0002-3437-5666)
- Signe Bech Sørensen
- Guillaume Hekimian
- Trine Mogensen
- Guy Gorochov
- Merete Storgaard
- MIS-A & COVID-19 Taskforce
- Marc Pineton de Chambrun
- Ann-Britt Eg Hansen
Institutions
- Université Claude Bernard Lyon 1 (FR)
- École Normale Supérieure de Lyon (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Laboratoire National de Référence (MA)
- Pitié-Salpêtrière Hospital (FR)
- Centre d'Immunologie et des Maladies Infectieuses (FR)
- Centre International de Recherche en Infectiologie (FR)
- Imation (United States) (US)
Publication Details
- Journal
- Journal of Human Immunity
- Published
- 2025-12-12
- DOI
- https://doi.org/10.70962/jhi.20250050
- Primary Topic
- Kawasaki Disease and Coronary Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00