Where you start could determine where you end up

A significant subset of the eukaryotic proteome must localize to multiple cellular compartments, necessitating the emergence of mechanisms to produce protein isoforms with distinct targeting sequences. Ly et al. reveal that alternative start-codon selection during translation initiation is a pervasive mechanism for dual localization of proteins by generating N-terminal isoforms.

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Journal
Trends in Cell Biology
Published
2026-01-08
DOI
https://doi.org/10.1016/j.tcb.2025.12.003
Primary Topic
RNA and protein synthesis mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Where you start could determine where you end up

Cecilia A. Leber, Hani S. Zaher
Trends in Cell Biology
RNA and protein synthesis mechanisms
article

Where you start could determine where you end up

Cecilia A. Leber, Hani S. Zaher
article en

Abstract

A significant subset of the eukaryotic proteome must localize to multiple cellular compartments, necessitating the emergence of mechanisms to produce protein isoforms with distinct targeting sequences. Ly et al. reveal that alternative start-codon selection during translation initiation is a pervasive mechanism for dual localization of proteins by generating N-terminal isoforms.

Trends in Cell BiologyVol. 36(2)
Washington University in St. Louis (US)
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Openalex Percentile: Top 93%
RNA and protein synthesis mechanisms
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Where you start could determine where you end up — Cecilia A. Leber, Hani S. Zaher · Trends in Cell Biology (2026) | TGRS Research Map | TGRS