Visceral Adiposity Threshold for Irreversible Hypothalamic-Pituitary-Gonadal Axis Suppression: The Aromatase-SHBG Saturation Hypothesis

Obesity is strongly associated with male hypogonadism, yet weightloss yields inconsistent improvements in testosterone levels across individuals. Themechanisms underlying this heterogeneity remain poorly understood.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-01-05
DOI
https://doi.org/10.5281/zenodo.18150261
Primary Topic
Hypothalamic control of reproductive hormones
Type
article
Field-Weighted Citation Impact
0.00
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article

Visceral Adiposity Threshold for Irreversible Hypothalamic-Pituitary-Gonadal Axis Suppression: The Aromatase-SHBG Saturation Hypothesis

Ionut Alexandru Stefan
Zenodo (CERN European Organization for Nuclear Research)
Hypothalamic control of reproductive hormones
article

Visceral Adiposity Threshold for Irreversible Hypothalamic-Pituitary-Gonadal Axis Suppression: The Aromatase-SHBG Saturation Hypothesis

Ionut Alexandru Stefan
article en

Abstract

Obesity is strongly associated with male hypogonadism, yet weightloss yields inconsistent improvements in testosterone levels across individuals. Themechanisms underlying this heterogeneity remain poorly understood.

Zenodo (CERN European Organization for Nuclear Research)
Zero hunger
Openalex Percentile: Top 93%
Hypothalamic control of reproductive hormones
DOIOpen Access PDFOpenAlex
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Visceral Adiposity Threshold for Irreversible Hypothalamic-Pituitary-Gonadal Axis Suppression: The Aromatase-SHBG Saturation Hypothesis — Ionut Alexandru Stefan · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS