15 01 Base Architecture HG Prostatic Adenocarcinoma

Prostatic adenocarcinoma exhibits remarkable heterogeneity and therapeutic resistance, particularly in high-grade (Gleason ≥ 8) cases. Traditional approaches treat this disease as a monolithicentity characterized by androgen dependency and uncontrolled proliferation. However, emerging evidence suggests that high-grade prostatic tumors represent complex ecosystems comprisingmultiple cellular archetypes occupying distinct spatial niches, each governed by specific ecosistem equilibria.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-01-06
DOI
https://doi.org/10.5281/zenodo.18166901
Primary Topic
Prostate Cancer Treatment and Research
Type
article
Field-Weighted Citation Impact
0.00
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article

15 01 Base Architecture HG Prostatic Adenocarcinoma

Ionut Alexandru Stefan
Zenodo (CERN European Organization for Nuclear Research)
Prostate Cancer Treatment and Research
article

15 01 Base Architecture HG Prostatic Adenocarcinoma

Ionut Alexandru Stefan
article en

Abstract

Prostatic adenocarcinoma exhibits remarkable heterogeneity and therapeutic resistance, particularly in high-grade (Gleason ≥ 8) cases. Traditional approaches treat this disease as a monolithicentity characterized by androgen dependency and uncontrolled proliferation. However, emerging evidence suggests that high-grade prostatic tumors represent complex ecosystems comprisingmultiple cellular archetypes occupying distinct spatial niches, each governed by specific ecosistem equilibria.

Zenodo (CERN European Organization for Nuclear Research)
Life in Land
Openalex Percentile: Top 93%
Prostate Cancer Treatment and Research
DOIOpen Access PDFOpenAlex
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15 01 Base Architecture HG Prostatic Adenocarcinoma — Ionut Alexandru Stefan · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS