Impact of Neoadjuvant Induction Chemotherapy Prior to Chemoradiation on Survival and Surgical Outcomes in Real-World Esophageal Adenocarcinoma Cohort
In this real-world, single-institutional patient cohort investigating induction chemotherapy prior to chemoradiation in EAC, patients receiving induction chemotherapy did well but did not have a statistically significant improvement in survival outcomes or surgical outcomes. This study showed that significant numbers of real-world patients may not receive esophagectomy. Thus, prospective, randomized clinical trials are warranted to better delineate the efficacy and selection of patients for induction chemotherapy when non-operative approaches are favored.
Authors
- Mario Gasparri
- Thomas Matoska
- Elizabeth Gore
- Monica Shukla (ORCID: https://orcid.org/0000-0001-5146-0240)
- A. Banerjee
- Alexandria T. Phan (ORCID: https://orcid.org/0000-0002-2953-3033)
- Lauren Jurkowski (ORCID: https://orcid.org/0000-0002-2716-0448)
- Abdullah A. Memon (ORCID: https://orcid.org/0009-0009-9062-7619)
- Lou-Anne Acevedo Moreno
- C. Johnstone (ORCID: https://orcid.org/0000-0003-0283-2946)
- Calista Bulacan
- Ben George
- Mallory Hunt
- Lisa Rein
- Paul Linsky
- Lindsay L. Puckett
Institutions
- Mayo Clinic (US)
- NorthShore University HealthSystem (US)
- Medical College of Wisconsin (US)
Publication Details
- Journal
- Cancers
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3390/cancers18020213
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00