Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting In-Hospital Mortality in Patients With Diabetic Foot Ulcers Undergoing Amputation: A Retrospective Study

Elevated postoperative NLR and PLR are independent predictors of in-hospital mortality in DFU patients undergoing MLLA. These readily available biomarkers can assist in early risk stratification and guide postoperative management. The study also provides region-specific data on microbial prevalence and antibiotic susceptibility, supporting more targeted empiric therapy in this high-risk population.

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Publication Details

Journal
Cureus
Published
2026-01-08
DOI
https://doi.org/10.7759/cureus.101089
Primary Topic
Inflammatory Biomarkers in Disease Prognosis
Type
article
Field-Weighted Citation Impact
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article

Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting In-Hospital Mortality in Patients With Diabetic Foot Ulcers Undergoing Amputation: A Retrospective Study

Uday Shamrao Kumbhar, Bharath Nagarajan, Abhinaya Reddy, Rajeswari Murugesan et al.
Cureus
Inflammatory Biomarkers in Disease Prognosis
article

Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting In-Hospital Mortality in Patients With Diabetic Foot Ulcers Undergoing Amputation: A Retrospective Study

Uday Shamrao Kumbhar, Bharath Nagarajan, Abhinaya Reddy, Rajeswari Murugesan, Bhagyasri P
article en

Abstract

Elevated postoperative NLR and PLR are independent predictors of in-hospital mortality in DFU patients undergoing MLLA. These readily available biomarkers can assist in early risk stratification and guide postoperative management. The study also provides region-specific data on microbial prevalence and antibiotic susceptibility, supporting more targeted empiric therapy in this high-risk population.

CureusVol. 18(1)
Jawaharlal Institute of Post Graduate Medical Education and Research (IN), All India Institute of Medical Sciences (IN)
Good health and well-being
Openalex Percentile: Top 93%
Inflammatory Biomarkers in Disease Prognosis
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