Identification of novel circulating protein biomarkers for hepatocellular carcinoma superior to alpha-fetoprotein through a stemness index and secretome analysis
This multi-omics study reveals a panel of eight circulating proteins with diagnostic performance superior to that of AFP and independent prognostic value in HCC, nominating NENF as a causal biomarker for disease progression and survival.
Authors
- Ji-Sook Han (ORCID: https://orcid.org/0000-0002-6282-6815)
- Xinwei Liu (ORCID: https://orcid.org/0000-0002-5358-886X)
- Sha Yan
- Cai Gao
- Xiaodan Ran
Institutions
- First Affiliated Hospital of Henan University of Traditional Chinese Medicine (CN)
- Zhengzhou People's Hospital (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1186/s12957-025-04189-z
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00