Clinical translation of fluid, imaging, and digital biomarkers for Alzheimer’s disease
Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disorder, affecting millions worldwide. The clinical presentation of AD is heterogenous and often complicated by the presence of multiple co-pathologies, which can overlap with features of other neurodegenerative disorders, underscoring the need for tools to aid accurate and timely diagnosis. Biomarkers for AD span multiple modalities and are being increasingly used in clinical settings to aid diagnosis, monitor disease progression, and assess eligibility and response to disease-modifying therapies. Here, we provide an overview of current clinical applications of fluid, imaging, and digital biomarkers for AD. We also discuss biomarkers under development and challenges associated with the implementation of these modalities in clinical settings.
Authors
- Ayesha Fawad (ORCID: https://orcid.org/0000-0002-7918-5217)
- Zampeta-Sofia Alexopoulou (ORCID: https://orcid.org/0000-0002-7304-0834)
- Sandar Aye (ORCID: https://orcid.org/0000-0003-1360-4834)
- Shirine Moukaled (ORCID: https://orcid.org/0000-0001-5421-8038)
- Prithvi Arunachalam (ORCID: https://orcid.org/0000-0002-0798-6250)
- Aram Aslanyan (ORCID: https://orcid.org/0000-0003-3220-6313)
- Ross W. Paterson (ORCID: https://orcid.org/0000-0001-9372-3635)
- Ana Sabsil López Rocha
- Monica Crugel
- Claudia Tato-Fernández (ORCID: https://orcid.org/0009-0008-8448-8678)
- Stamatia Karagianni (ORCID: https://orcid.org/0009-0006-2505-770X)
- Aitana Sogorb-Esteve
- Michael Schöll
- Alexandra König
- Julia R. Bacci
Institutions
- Tulane University (US)
- Oxleas NHS Foundation Trust (GB)
- University of Turku (FI)
- Lund University (SE)
- Université Côte d'Azur (FR)
- Sahlgrenska University Hospital (SE)
- Turku University Hospital (FI)
- Karolinska Institutet (SE)
- Centre Hospitalier Universitaire de Nice (FR)
- Turku PET Centre (FI)
- Amsterdam Neuroscience (NL)
- UK Dementia Research Institute (GB)
- MRC Prion Unit (GB)
- Cognition Behaviour Technology (FR)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Wake Forest University (US)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1186/s13195-025-01921-5
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00