Global glucagon-like peptide-2 receptor activation linked to increased obesity risk in the UK Biobank
Our findings suggest that global GLP-2R activation, encompassing the effects across all tissues, is associated with increased risk of obesity. This study highlights the role of the GLP-2R in metabolic diseases, guiding the future development of biased GLP-2R ligands and the potential adverse effects of GLP-2R modulation.
Authors
- Alexander S. Hauser (ORCID: https://orcid.org/0000-0003-1098-6419)
- Peter Lindquist (ORCID: https://orcid.org/0000-0002-8120-3074)
- Jakob Sture Madsen (ORCID: https://orcid.org/0000-0002-2841-7284)
- P. Gerlach (ORCID: https://orcid.org/0009-0000-7108-0026)
- Felix Faas (ORCID: https://orcid.org/0000-0002-2596-045X)
- Sarina Gadgaard (ORCID: https://orcid.org/0000-0001-6995-7933)
- Maria B.N. Gabe
- Javier Sanchez Lorente
- Mette M. Rosenkilde
Institutions
- University of Copenhagen (DK)
Publication Details
- Journal
- Metabolism
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1016/j.metabol.2025.156489
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- European Foundation for the Study of Diabetes
- Lundbeckfonden
- Novo Nordisk
- Novo Nordisk Fonden
- H. Lundbeck A/S