MiR-31 suppresses lung adenocarcinoma cell proliferation through CDK1 and E2F2-mediated cell cycle arrest

Collectively, our study establishes miR-31 as a novel biomarker for LUAD proliferative potential and implicates the miR-31/CDK1-E2F2 network as a promising target for disrupting LUAD progression. These findings establish a miRNA-centric precision therapeutic paradigm for effectively suppressing oncogenic proliferation in LUAD.

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Publication Details

Journal
Discover Oncology
Published
2026-01-09
DOI
https://doi.org/10.1007/s12672-025-04362-6
Primary Topic
MicroRNA in disease regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

MiR-31 suppresses lung adenocarcinoma cell proliferation through CDK1 and E2F2-mediated cell cycle arrest

Shanshan Wang, Yulin He, Chenjing Lin, Pan Sun et al.
Discover Oncology
MicroRNA in disease regulation
article

MiR-31 suppresses lung adenocarcinoma cell proliferation through CDK1 and E2F2-mediated cell cycle arrest

Shanshan Wang, Yulin He, Chenjing Lin, Pan Sun, Man Zhang, Jizhuang Luo, Yi Tian, Kai Wang
article en

Abstract

Collectively, our study establishes miR-31 as a novel biomarker for LUAD proliferative potential and implicates the miR-31/CDK1-E2F2 network as a promising target for disrupting LUAD progression. These findings establish a miRNA-centric precision therapeutic paradigm for effectively suppressing oncogenic proliferation in LUAD.

Discover OncologyVol. 17(1)
Shanghai Jiao Tong University (CN), Shanghai Chest Hospital (CN), Fujian Provincial People's Hospital (CN), Fujian Provincial Hospital (CN), Dazhou Central Hospital (CN), Xiangyang Hospital of Traditional Chinese Medicine (CN)
Good health and well-being
Openalex Percentile: Top 93%
MicroRNA in disease regulation
DOIOpen Access PDFOpenAlex
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MiR-31 suppresses lung adenocarcinoma cell proliferation through CDK1 and E2F2-mediated cell cycle arrest — Shanshan Wang, Yulin He, et al. · Discover Oncology (2026) | TGRS Research Map | TGRS