Central hypocretin/orexin administration alleviates sleep/wake disturbances, anhedonia, and neuroinflammation in an animal model of seasonal affective disorder
These findings support the hypothesis that the orexinergic system mediates the effects of ambient light on sleep and affect, and may be a potential therapeutic target in SAD.
Authors
- Allison Costello (ORCID: https://orcid.org/0000-0001-7119-3194)
- Jiaming Shi
- Katrina Linning-Duffy
- Joseph S. Lonstein
- Lily Yan
Institutions
- Behavioral Pharma (United States) (US)
- California Institute of Behavioral Neurosciences and Psychology (United States) (US)
- Michigan State University (US)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1080/07853890.2025.2611202
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00