Photocatalytic Hydroxyalkylation of Heteroarenes with Aldehydes
The photoredox hydroxyalkylation of heteroaromatics with aldehydes proceeds under mild and neutral conditions. This transition-metal- and oxidant-free hydroxyalkylation proceeds efficiently with various heteroarenes and aldehydes and has been applied to the late-stage modification of pharmaceutically active molecules, and on a gram-scale. (PhO)<sub>2</sub>PO<sub>2</sub>H plays multiple roles in this transformation, including protonation, hydrogen atom transfer (HAT) and electron transfer.
Authors
- D. Young
- Zhi‐Gang Ren (ORCID: https://orcid.org/0000-0002-0740-8397)
- Mingfei Li (ORCID: https://orcid.org/0000-0003-4040-3392)
- Xinhua Lu (ORCID: https://orcid.org/0000-0003-4831-7456)
- Hong-Xi Li
- Beibei Wang
Institutions
- University of Glasgow (GB)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1021/acs.joc.5c02854
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00