Metabolomic analysis identifies alterations of amino acids in the tears and plasma of patients with dry eye disease with ocular pain
MET in tear fluid and 1-MEHIS in plasma were significantly associated with DED with ocular pain, showing promise as potential biomarkers for DED with ocular pain. Further validation through large-scale studies is warranted.
Authors
- Yanning Yang (ORCID: https://orcid.org/0009-0004-7514-0128)
- Kuiliang Yang
- Jiewen Mao (ORCID: https://orcid.org/0000-0003-4751-225X)
- Lan Ke
- Yujin Wang
- Qingyan Zeng
- Yiqiao Xing
- Wanju Yang
- Dongping Li
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Wuhan Hankou Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fmed.2025.1733856
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Program of Hunan Province