Ubiquitin-specific protease 19 promotes M2 macrophage polarization and ovarian cancer progression via NLRP3 suppression
USP19 drives EOC progression by promoting M2 macrophage polarization and suppressing NLRP3-mediated inflammatory responses. Targeting USP19 may represent a novel therapeutic strategy to modulate the tumor immune microenvironment and inhibit EOC progression.
Authors
- Jinbao Zhang
- Ying Pang
Institutions
- Shanxi Medical University (CN)
- Shaanxi Provincial People's Hospital (CN)
- Xijing Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1007/s12672-025-04381-3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00