Clonal replacement by a P1-1/ST3 lineage in pediatric Mycoplasma pneumoniae, Jinan, China, 2021–2024
The 2023-2024 resurgence coincided with clonal replacement by P1-1/ST3 in a setting of fixed macrolide resistance and an increase in severe pediatric disease. Given the retrospective, culture-based design, this should be interpreted as a temporal association rather than evidence that ST3 intrinsically caused more severe disease. These findings support consideration of non-macrolide agents in similar high-resistance settings and motivate prospective genomic-clinical surveillance.
Authors
- H N Zhang
- Ming Fang
- Lu Yuan
- T. C. Liu
- X H Yu
- Jianmei Yu
- Shuang Wang
- Xiao Wang
- Haijian Zhou
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Neijiang Normal University (CN)
- National Institute for Communicable Disease Control and Prevention (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Shandong Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fcimb.2025.1732239
- Primary Topic
- Microbial infections and disease research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province