Multi-institutional Normal Tissue Complication Probability (NTCP) Prediction Model for Mandibular Osteoradionecrosis: Results from the PREDMORN Study
The PREDMORN NTCP model is the largest multi-institutional effort to date aimed at predicting ORN risk in patients with HNC using real-world data. The model demonstrated good generalizability when externally validated to a large population-based cohort. Our observations align with current guidelines and corroborate findings from smaller single-institution studies.
Authors
- Johannes A. Langendijk (ORCID: https://orcid.org/0000-0003-1083-372X)
- A. van der Schaaf (ORCID: https://orcid.org/0000-0003-4067-7975)
- Lisanne V. van Dijk (ORCID: https://orcid.org/0000-0002-9515-5616)
- Erin Watson (ORCID: https://orcid.org/0000-0002-8219-8318)
- Irene Oliveras Cancio (ORCID: https://orcid.org/0009-0001-7837-6564)
- Katrina Hueniken (ORCID: https://orcid.org/0000-0003-1376-8046)
- Peter B. Reich (ORCID: https://orcid.org/0000-0003-4424-662X)
- Steven Petit (ORCID: https://orcid.org/0000-0001-9787-8239)
- L. Humbert-Vidan
- Mohammad Moharrami (ORCID: https://orcid.org/0000-0002-4364-7969)
- Andrew P. King (ORCID: https://orcid.org/0000-0003-1277-8509)
- Gerda M. Verduijn (ORCID: https://orcid.org/0000-0002-3513-6544)
- Vinod F. Patel
- Jordi Marruecos Querol
- Stephen Y. Lai (ORCID: https://orcid.org/0000-0001-8301-7286)
- Christian Rønn Hansen (ORCID: https://orcid.org/0000-0001-5716-6069)
- Mike Oliver
- Abdul Ahad Khan (ORCID: https://orcid.org/0000-0002-3915-9102)
- Andrew Pearce
- Deborah Saunders
- Ali Hosni
- Wilma D Heemsbergen
- Andrew Hope
- Amy C. Moreno
- Clifton D. Fuller
- Jørgen Johansen
- Carles Muñoz-Montplet
- Max Witjes
- Suzanne P.M. de Vette
- Abdallah S. R. Mohamed
Institutions
- University Health Network (CA)
- University Medical Center Groningen (NL)
- The University of Texas MD Anderson Cancer Center (US)
- University of Groningen (NL)
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Universitat de Girona (ES)
- Catalan Institute for Water Research (ES)
- Odense University Hospital (DK)
- Princess Margaret Cancer Centre (CA)
- Health Sciences North (CA)
- Clínica Girona (ES)
- Institut Català d'Oncologia (ES)
- Erasmus MC Cancer Institute (NL)
- NOSM University (CA)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.ijrobp.2025.12.044
- Primary Topic
- Oral health in cancer treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Elekta
- Cancer Research UK
- Siemens Healthineers