Trastuzumab deruxtecan efficacy, FcRn-facilitated penetration of the blood-tumor barrier, and distribution to tumor cells in HER2+ brain metastasis model systems
The data confirm T-DXd activity in HER2+ brain metastases and identify important correlates including heterogeneous uptake, variable HER2 expression at endpoint, tumor cell cytotoxicity, decreased proliferation, and BTB transcytosis.
Authors
- Patricia S. Steeg (ORCID: https://orcid.org/0000-0002-2626-0594)
- Debbie Wei
- Imran Khan (ORCID: https://orcid.org/0000-0001-6888-7347)
- Ross Lake (ORCID: https://orcid.org/0000-0002-6929-0793)
- C. Scott. Robinson
- Dinesh Kumar (ORCID: https://orcid.org/0000-0002-3890-326X)
- Ronald A. Fleming
- Wei Zhang
- Stanley Lipkowitz
Institutions
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
- Daiichi Sankyo (United States) (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1093/neuonc/noag002
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00