Immature squamous metaplastic epithelium of Weber’s glandular duct: a significant origin of HPV-independent oropharyngeal squamous cell carcinoma in the base of the tongue

Weber's glandular ducts are an important origin of HPV-independent OPSCC. The first animal model replicating this process offers an essential platform for studying HPV-independent OPSCC.

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Publication Details

Journal
Journal of Cancer Research and Clinical Oncology
Published
2026-01-08
DOI
https://doi.org/10.1007/s00432-025-06415-3
Primary Topic
Head and Neck Cancer Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Immature squamous metaplastic epithelium of Weber’s glandular duct: a significant origin of HPV-independent oropharyngeal squamous cell carcinoma in the base of the tongue

Lanzhu Lin, Renchuan Tao, Xinyu Chen, Lin Luo et al.
Journal of Cancer Research and Clinical Oncology
Head and Neck Cancer Studies
article

Immature squamous metaplastic epithelium of Weber’s glandular duct: a significant origin of HPV-independent oropharyngeal squamous cell carcinoma in the base of the tongue

Lanzhu Lin, Renchuan Tao, Xinyu Chen, Lin Luo, Qiaozhi Jiang, Dahai Yu, Siyu Liu, Ping Li
article en

Abstract

Weber's glandular ducts are an important origin of HPV-independent OPSCC. The first animal model replicating this process offers an essential platform for studying HPV-independent OPSCC.

Journal of Cancer Research and Clinical OncologyVol. 152(1)
Guangxi Medical University (CN), First Affiliated Hospital of GuangXi Medical University (CN), Guangxi Center for Disease Prevention and Control (CN)
Openalex Percentile: Top 93%
Head and Neck Cancer Studies
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