Research Advances of RNA N⁶-Methyladenosine Modification in Arsenic-Induced Multi-Organ Damage.

Arsenic is a widespread carcinogen in the environment,and chronic arsenic exposure results in dysfunction or even cancer development of multiple organs,including the skin,liver,lung,brain,and ovary.RNA N⁶-methyladenosine(m⁶A)is a ubiquitous epigenetic modification of RNA in eukaryotes,regulating numerous physiological and pathological processes in cells.Increasing studies have shown that m⁶A plays a crucial role in arsenic-induced damage of multiple organs and systems,including the skin,liver,lung,nervous system,reproductive system,and embryo.This paper summarizes the recent studies on the regulatory role of m⁶A in arsenic-induced damage,providing new ideas and directions for the investigation of the mechanism and treatment strategy of arsenic toxicity.