<i>ESR1</i> Mutation in Endocrine Treatment-Naïve Endometrial Cancer: Prevalence, Characteristics, and Prognostic Implications, Results from the UTOLA Phase II GINECO Trial
ESR1 mutations, while rare overall in treatment-naïve endometrial cancer, are more prevalent in patients with NSMP low-grade endometrioid endometrial cancer, potentially affecting AI efficacy. ESR1 status should be considered in selecting hormonotherapy and as a stratification factor in AI trials.
Authors
- A. Leary
- Corina Cornila
- Coriolan Lebreton (ORCID: https://orcid.org/0000-0002-4275-1721)
- P. Fournel (ORCID: https://orcid.org/0000-0002-3884-6816)
- Guillaume Beinse (ORCID: https://orcid.org/0000-0003-2731-6462)
- F. Blanc-Durand
- Elise Bonnet (ORCID: https://orcid.org/0000-0002-7061-0993)
- Patrick Bouchaert (ORCID: https://orcid.org/0009-0009-2111-4166)
- Yolanda Fernandez Diez
- Guillaume Meynard
- Emilie Kaczmarek (ORCID: https://orcid.org/0000-0002-2633-3773)
- D. Duliege
- F. Selle
- David Church
- S. Nikolaev
- Antoine Arnaud
- Philippe Follana (ORCID: https://orcid.org/0000-0001-6999-462X)
- L. Bengrine Lefevre
- Pierre-Emmanuel Brachet (ORCID: https://orcid.org/0000-0003-3303-2634)
- Catherine Genestie
- Isabelle Cojean Zelek
- Raphael Leman
- Florence Joly
- Marie Ange Mouret-Reynier
- Anne-Claire Hardy-Bessard
- Jérôme Alexandre
- Sophie Roche
- Olivier Tredan
Institutions
- Université d'Orléans (FR)
- Inserm (FR)
- Université d'Avignon et des Pays de Vaucluse (FR)
- CEA Valduc (FR)
- Institut Gustave Roussy (FR)
- University of Oxford (GB)
- Centre Hospitalier Universitaire de Besançon (FR)
- Hôpital Cochin (FR)
- Centre Georges François Leclerc (FR)
- Centre François Baclesse (LU)
- Centre Hospitalier Universitaire de Nîmes (FR)
- Centre Léon Bérard (FR)
- Délégation Centre-Est (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Groupe Hospitalier Mutualiste de Grenoble (FR)
- Groupe Hospitalier Diaconesses Croix Saint-Simon (FR)
- Institut Génétique Nantes Atlantique (FR)
- Laboratoire Informatique d'Avignon (FR)
- Centre François Baclesse (FR)
- Centre Jean Bernard (FR)
- Centre Jean Perrin (FR)
- Centre Oscar Lambret (FR)
- Institut Bergonié (FR)
- Arcagy Gineco (FR)
- Centre hospitalier universitaire d'Orléans (FR)
- Centre Hospitalier René-Dubos (FR)
- Eau de Paris (France) (FR)
- Centro Universitário Carioca (BR)
- Centre Antoine Lacassagne (FR)
- Centre Hospitalier Universitaire de Saint-Étienne (FR)
- Hôpital Intercommunal de Créteil (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2758
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00