Porphyromonas gingivalis-derived outer membrane vesicles promote vascular endothelial glycocalyx injury via the PPAD/CitH3/B3GAT1 pathway
Our experiments demonstrated that biomarkers of endothelial glycocalyx injury were significantly higher in patients with stage III-IV periodontitis and PPAD could enter the cell nucleus, playing a vital role in vascular endothelial glycocalyx injury through the CitH3/B3GAT1 pathway.
Authors
- Ziming Ge
- Yaping Pan
- Muzhou Jiang (ORCID: https://orcid.org/0000-0003-4877-3603)
- Lijie Lu (ORCID: https://orcid.org/0000-0002-6309-5508)
- Hanyu Gao
- Zhaorong Li
- Chen Li
- Li Lin
- Shoucheng Yin
- Qihui Qiao
Institutions
- Liaoning University (CN)
- Shenyang Center for Disease Control and Prevention (CN)
- Liaoning Provincial People's Hospital (CN)
- Stomatology Hospital (CN)
- China Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1186/s12951-025-04015-4
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00