Upregulation of miR-223 by SIRT1 attenuates the inflammatory response in neonatal sepsis

Overexpression of SIRT1 upregulated miR-223 expression, which attenuated the LPS-induced neutrophil activity and inflammatory response. The SIRT1/miR-223 signaling axis provides a potential therapeutic target for the clinical management of neonatal sepsis.

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Publication Details

Journal
BMC Immunology
Published
2026-01-09
DOI
https://doi.org/10.1186/s12865-025-00793-6
Primary Topic
Sirtuins and Resveratrol in Medicine
Type
article
Field-Weighted Citation Impact
0.00
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article

Upregulation of miR-223 by SIRT1 attenuates the inflammatory response in neonatal sepsis

Ai Yan, Xuening Wang, Chang Lu
BMC Immunology
Sirtuins and Resveratrol in Medicine
article

Upregulation of miR-223 by SIRT1 attenuates the inflammatory response in neonatal sepsis

Ai Yan, Xuening Wang, Chang Lu
article en

Abstract

Overexpression of SIRT1 upregulated miR-223 expression, which attenuated the LPS-induced neutrophil activity and inflammatory response. The SIRT1/miR-223 signaling axis provides a potential therapeutic target for the clinical management of neonatal sepsis.

BMC ImmunologyVol. 27(1)
Peking University (CN), Peking University International Hospital (CN), Xi’an Children’s Hospital (CN), Yiwu Science and Technology Research Institute (CN)
Good health and well-being
Openalex Percentile: Top 94%
Sirtuins and Resveratrol in Medicine
DOIOpen Access PDFOpenAlex
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