Repurposing GLP-1 receptor agonists for alcohol use disorder: a systematic review and meta-analysis
GLP-1RA use was associated with a reduced risk of AUD diagnosis, with a possible but non-significant reduction in alcohol-related hospitalization. Effects may be mediated through modulation of mesolimbic reward pathways and the gut-brain axis. Further large-scale trials are warranted to confirm these findings.
Authors
- Ghazaleh Kheiri (ORCID: https://orcid.org/0000-0001-6272-2402)
- Amir Nasrollahizadeh (ORCID: https://orcid.org/0000-0001-6328-8468)
- Seyedeh Fatemeh Hamzavi
- Ehsan Amini-Salehi
- Mehdi Karimi
- Sadra Kheiri
- Mohammad Amin Karimi
- Sepide Javankiani
Institutions
- Isfahan University of Medical Sciences (IR)
- Guilan University of Medical Sciences (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
- Bogomolets National Medical University (UA)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1186/s13098-025-02006-x
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00