Rhapontigenin alleviates cellular senescence and physiological aging by upregulating sirt1 and promoting autophagy
Rhap is a promising candidate for mitigating age-related cellular and physiological decline by reducing cellular senescence, promoting autophagy, and modulating immune function. However, further work is needed to fully elucidate the precise molecular mechanisms of Rhap's action and its pharmacokinetic profile to assess its translational potential in humans.
Authors
- Ming Li (ORCID: https://orcid.org/0000-0002-8827-9186)
- Yueran Zhao (ORCID: https://orcid.org/0000-0002-2218-4918)
- Yan Liu (ORCID: https://orcid.org/0000-0003-2649-2552)
- G. Xu
- Yunna Ning
- Guolong Wang
- Shuang Liu
- Yuxuan Shi
- Wendi Chen
- Yongzhi Cao
Institutions
- Shandong University (CN)
- State Key Laboratory of Reproductive Medicine
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1186/s13020-025-01319-3
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 32.84