Modeling the dynamics of hepatic metabolism: the predominance of 12-hour rhythmicity in metabolic adaptation
Hepatic metabolic functions follow a 12-hour cycle rather than a 24-hour cycle, significantly contributing to the liver's ability to meet nutrient demands throughout the day. Mitochondrial dynamics, which are influenced by nutrient availability, play a central role in adapting energy production to the body's metabolic needs.
Authors
- Andrej Shevchenko (ORCID: https://orcid.org/0000-0002-5079-1109)
- Nikolaus Berndt (ORCID: https://orcid.org/0000-0001-5594-9940)
- Iwona Wallach (ORCID: https://orcid.org/0000-0002-4968-6475)
- Eugenia Marbach-Breitrück (ORCID: https://orcid.org/0000-0003-4717-510X)
- Madlen Matz‐Soja (ORCID: https://orcid.org/0000-0002-5929-3704)
- Christiane Körner (ORCID: https://orcid.org/0000-0001-8753-8441)
- Christian Bergmann (ORCID: https://orcid.org/0000-0002-7482-5617)
- Fritzi Ott (ORCID: https://orcid.org/0000-0001-7225-4809)
- Michael Mülleder (ORCID: https://orcid.org/0000-0001-9792-3861)
- Janett Fischer
- Rolf Gebhardt
- Ute Hofmann
- Thomas Berg
Institutions
- Humboldt-Universität zu Berlin (DE)
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
- Max Planck Institute of Molecular Cell Biology and Genetics (DE)
- German Institute of Human Nutrition (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1007/s00018-025-06046-4
- Citations
- 2
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 51.75