Gut microbiota dysbiosis aggravates sepsis-induced lung injury by promoting neutrophil extracellular traps and suppressing host integrin defense

We unveil a novel gut microbiota-NET-integrin axis in sepsis-induced ALI, where microbial dysbiosis promotes NET-mediated suppression of ITGAM/ITGB2, leading to endothelial barrier failure. Our findings position FMT and integrin modulation as promising strategies to mitigate pulmonary vascular dysfunction, advancing the therapeutic potential of microbiota-targeted interventions in critical care.