Impact of Anti‐Endometrial Antibodies on IVF Implantation and Pregnancy Outcomes: A Retrospective Study

Our study observed that the presence of EMAb was associated with less favorable IVF outcomes, primarily reflected in lower implantation and clinical pregnancy rates. However, once the implantation was successful, the risk of miscarriage did not increase. These findings suggest a potential role for EMAb screening in guiding personalized treatment strategies, such as increasing the number of embryos transferred or using immunosuppressive agents, to improve IVF outcomes. Future research should involve more extensive and diverse populations to explore the mechanisms of action of EMAb and their impact on IVF treatment outcomes.

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Publication Details

Journal
American Journal of Reproductive Immunology
Published
2026-01-01
DOI
https://doi.org/10.1111/aji.70202
Primary Topic
Reproductive System and Pregnancy
Type
article
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article

Impact of Anti‐Endometrial Antibodies on IVF Implantation and Pregnancy Outcomes: A Retrospective Study

Xiaojing Hou, Huiqing An, Yan Su, Yuhe Wang et al.
American Journal of Reproductive Immunology
Reproductive System and Pregnancy
article

Impact of Anti‐Endometrial Antibodies on IVF Implantation and Pregnancy Outcomes: A Retrospective Study

Xiaojing Hou, Huiqing An, Yan Su, Yuhe Wang, Juan Zhang, Yaping Guo, Xiufeng Ling, Rong Shen, Shuangshuang Zhao, Mianqiu Zhang
article en

Abstract

Our study observed that the presence of EMAb was associated with less favorable IVF outcomes, primarily reflected in lower implantation and clinical pregnancy rates. However, once the implantation was successful, the risk of miscarriage did not increase. These findings suggest a potential role for EMAb screening in guiding personalized treatment strategies, such as increasing the number of embryos transferred or using immunosuppressive agents, to improve IVF outcomes. Future research should involve more extensive and diverse populations to explore the mechanisms of action of EMAb and their impact on IVF treatment outcomes.

American Journal of Reproductive ImmunologyVol. 95(1)
Nanjing Maternity and Child Health Care Hospital (CN)
Good health and well-being
Openalex Percentile: Top 93%
Reproductive System and Pregnancy
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Impact of Anti‐Endometrial Antibodies on IVF Implantation and Pregnancy Outcomes: A Retrospective Study — Xiaojing Hou, Huiqing An, et al. · American Journal of Reproductive Immunology (2026) | TGRS Research Map | TGRS