Car@PLGA-NPs target gut microbiota-ER stress axis to combat diabetes
Collectively, this study confirms that the PLGA nanocarrier effectively enhances carvacrol bioavailability. Car@PLGA-NPs improve islet function and intestinal homeostasis in diabetic mice by remodeling the gut microbiota and subsequently inhibiting ER stress in pancreatic and intestinal tissues, providing a novel nano-drug delivery system and a "microbiota-ER stress" regulatory axis for diabetes treatment.
Authors
- Pingzhen Tong
- Li Tat John Chen
- Lijuan Xiong
- Jing Qing
- Ziruo Huang
- Wei ZHAO
- Yunzhi Chen
- Zhujia Zhao
Institutions
- Guiyang College of Traditional Chinese Medicine (CN)
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fcimb.2025.1667023
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00