Osteoarthritis pathogenesis Unveiled: DMT1 drives autophagy-dependent ferroptosis through a mir-17-5p/NEDD4 regulatory axis
This study not only elucidates a novel DMT1-autophagy-ferroptosis axis but also identifies NEDD4 as upstream therapeutic targets. The demonstration that Lip-1 treatment alleviates DMT1-driven OA exacerbation <i>in vivo</i> highlights translational potential of ferroptosis inhibition as a disease-modifying strategy for OA. Moreover, NEDD4 overexpression represents promising gene-based interventions with potential for precision therapy in OA.
Authors
- Gangyong Huang (ORCID: https://orcid.org/0009-0002-5292-0389)
- Jun Xia (ORCID: https://orcid.org/0000-0002-6823-4757)
- Jingsheng Shi
- Jingchun Ma
- Wei Wu (ORCID: https://orcid.org/0000-0002-5989-9458)
- X S Huang
- G F Zhao
- Y. Shen
- Jie Chen
- Siqun Wang
Institutions
- Fudan University (CN)
- Blood Center of Zhejiang Province (CN)
- Molecular Devices (United Kingdom) (GB)
- Second Affiliated Hospital of Zhejiang University (CN)
- Huashan Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.jot.2025.11.002
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00