The Runx2-SMOC axis in skeletal development: Expanding roles of Smoc1 and Smoc2 in development and disease
The Runx2-SMOC axis provides a mechanistic bridge between transcriptional programs and matricellular control of BMP2 signaling and ECM dynamics. Clarifying isoform-specific functions and ECM anchoring mechanisms will inform therapeutic strategies for skeletal disorders and broader pathologies in which SMOC proteins are implicated.
Authors
- Mitsuki Urushizaki
- Kenji Hata (ORCID: https://orcid.org/0000-0003-4367-9343)
- Yoshifumi Takahata (ORCID: https://orcid.org/0000-0002-3322-0515)
- Kanta Wakamori
- Tomohiko Murakami (ORCID: https://orcid.org/0000-0002-5021-5494)
- Miho Kakiuchi
- Riko Nishimura
- Maiko Omi-Sugihara
Institutions
- Chulalongkorn University (TH)
- Osaka University of Pharmaceutical Sciences (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1016/j.job.2026.100738
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00